Here is a sample of what is found online about this subject. Educate Yourself Wisely: The CB2 receptor type 2, also known as CB2₁, is a protein-gated ion channel in the marijuana and hashish receptor family in humans that is encoded by the CYP2E1 gene. The CB2 receptor is found in different parts of the body, including the brain, liver, intestines and pancreas. The CB2 receptor is responsible for the “high” that many marijuana users report feeling after smoking pot or ingesting hashish. In fact, the CB2 receptor has been shown to be an important player in the body’s ability to produce endocannabinoids, which are the chemicals that give marijuana and hashish its distinctive “high.”In addition to the ability of the CB2 receptor to produce the chemicals that give marijuana and hashish its high, it also has the ability to control the amount of receptors in a certain area of the brain that are important for the production of endocannabinoids. When these receptors are too many or too few in a certain area of the brain, the person can experience the effects of marijuana and hashish in a number of ways, including a decrease in the effects of certain drugs such as marijuana, and an increase in the effects of drugs like cocaine, heroin and methamphetamine. For this reason, CB2₁ levels can vary from one person to the next, depending on their overall health, genetic makeup and brain chemistry. For this reason, using marijuana and hashish when one’s brain has too little CB2₁ could result in an increased possibility of experiencing negative side effects.It is very important to realize that there is no single amount of marijuana or hashish that should be used to treat the symptoms of marijuana use, although some people believe that marijuana has a lower risk of causing adverse side effects than hashish or cocaine. It is recommended that one should consume a small amount of marijuana or hashish before they try any other drug, in order to determine if the effects of marijuana and hashish will cause any unwanted side effects. Even a very small amount of marijuana or hashish should be avoided by people who have a history of heart attacks, asthma or other conditions that could potentially interact with marijuana and hashish. This is because there is some evidence to suggest that marijuana and hashish may actually increase the risk of developing some types of diseases such as diabetes and pancreatic cancer. For those who already have conditions, it is best to avoid marijuana and hashish altogether until these conditions are under control.